Optimization of manufacture and examination of micropellets based on pharmaceutical technological and biopharmaceutical parameters

DOCTORAL (Ph.D.) DISSERTATION Optimization of manufacture and examination of micropellets based on pharmaceutical technological and biopharmaceutical parameters

Preformulation studies and optimization of floating drug delivery systems based on pharmaceutical technological and biopharmaceutical parameters

Design and Optimization of Novel Sugar Alcohol Based Extended Release Tablets Prepared by Melt Dispersion Technique

     The aim of this study is to prepare novel sorbitol based extended release tablets by melt dispersion method using carbamazepine as a model drug. Carbamazepine was melted along with sugar alcohol to get melt dispersion granules (MGDs) and was characterized by differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD) and solubility study. The physical and chemical parameters...

Optimum Swept Angle Estimation based on the Specific Cutting Energy in Milling AISI 1045 Steel Alloy

Mechanical machining processes are common manufacturing strategies to re-shape materials to desired specification. The mechanistic approach has revealed the mechanics of the machining processes with various parameters determined. The aim of this work is to investigate the impact of swept angle optimization and their influence on the specific cutting energy in milling AISI 1045 steel alloy. This...

Production Planning of Biopharmaceutical Manufacture

Multiproduct manufacturing facilities running on a campaign basis are increasingly becoming the norm for biopharmaceuticals, owing to high risks of clinical failure, regulatory pressures and the increasing number of therapeutics in clinical evaluation. The need for such flexible plants and cost-effective manufacture pose significant challenges for planning and scheduling, which are compounded b...